{"id":12455,"date":"2023-02-08T20:52:00","date_gmt":"2023-02-08T20:52:00","guid":{"rendered":"https:\/\/blogs.cooperhealth.org\/ehealth\/?p=12455"},"modified":"2023-02-10T18:31:28","modified_gmt":"2023-02-10T18:31:28","slug":"a-groundbreaking-approach-to-treating-advanced-melanoma-now-available-at-md-anderson-cancer-center-at-cooper","status":"publish","type":"post","link":"https:\/\/blogs.cooperhealth.org\/ehealth\/2023\/02\/08\/a-groundbreaking-approach-to-treating-advanced-melanoma-now-available-at-md-anderson-cancer-center-at-cooper\/","title":{"rendered":"A Groundbreaking Approach to Treating Advanced Melanoma \u2013 Now Available at MD Anderson Cancer Center at Cooper"},"content":{"rendered":"

\"A<\/p>\n

Para leer en Espa\u00f1ol, por favor haga clic aqu\u00ed<\/a><\/p>\n

Researchers at MD Anderson Cancer Center at Cooper<\/a> are leading the way in clinical trials of a new approach to treating advanced melanoma<\/a> using tumor infiltrating lymphocyte (TIL) therapy.<\/p>\n

\u201cTIL therapy is a promising, personalized approach to cancer treatment,\u201d says Young Ki Hong, MD<\/a>, MPH, surgical oncologist at MD Anderson at Cooper, and principal investigator of several TIL studies.<\/p>\n

\u201cResearch findings published in top medical journals, such as the New England Journal of Medicine<\/em>, have shown that TIL therapy not only prolongs the lives of those with advanced melanoma but also allows some to have complete responses, even after failing the previous standard-of-care immunotherapy,\u201d says Dr. Hong.<\/p>\n

Dr. Hong, who leads the TIL team at MD Anderson at Cooper, brings unique expertise in this treatment from his prior investigational work with TIL therapy at the National Institutes of Health.<\/p>\n

How TIL Therapy Works<\/h3>\n

After fighting cancer for so long, a patient\u2019s T cells are depleted and no longer effective. TIL therapy replaces these ineffective T cells with the patient\u2019s own<\/em> boosted, lab-grown T cells that can renew the fight against the melanoma.<\/p>\n

First, the melanoma tumor is removed from the patient and sent to a special lab. At the lab, the patient\u2019s cancer-fighting T cells are isolated from the tumor. They are revitalized, grown into billions of cells, and then frozen.<\/p>\n

When the new T cells are ready, the patient receives intensive chemotherapy treatment to eliminate regulatory cells, which suppress immune response in the body. Then the boosted, lab-grown T cells are returned to the patient through an infusion. At this point, the only T cells in the patient\u2019s body are their own supercharged cancer-fighting cells. Patients then receive between one and six doses of a medication called IL2, which further boosts effectiveness of the T cells.<\/p>\n

The patient\u2019s new T cells regenerate and form lasting memory cells, which continuously look for and attack new cancer cells.<\/p>\n

\u201cThe research has documented numerous patients who have been cured of their metastatic melanoma for over 10 years from this treatment,\u201d Dr. Hong says.<\/p>\n

\u201cThe team at MD Anderson at Cooper is proud to be one of the few select centers in the country that can deliver this personalized immunotherapy treatment to our patients. Our team is also taking part and leading clinical trials for the use of TIL therapy for other types of cancer, including metastatic non small cell lung cancer. This therapy has previously been used in treating patients with gynecologic cancers and head and neck cancers.\u201d<\/p>\n

To learn more about TIL therapy for advanced melanoma and other cancer clinical trials at MD Anderson at Cooper, call 855.MDA.COOPER<\/a>\u00a0(855.632.2667<\/a>) or email: researchcancer@cooperhealth.edu<\/a>.<\/p>\n

<\/a>
\n <\/p>\n

Un enfoque innovador para tratar el melanoma avanzado: ahora disponible en el MD Anderson Cancer Center en Cooper<\/h2>\n

Los investigadores del MD Anderson Cancer Center en Cooper<\/a> est\u00e1n liderando el camino en los ensayos cl\u00ednicos de un nuevo enfoque para tratar el melanoma<\/a> avanzado utilizando la terapia de linfocitos infiltrantes de tumores (TIL).<\/p>\n

“La terapia TIL es un enfoque prometedor y personalizado para el tratamiento del c\u00e1ncer”, dice Young Ki Hong, MD<\/a>, onc\u00f3logo quir\u00fargico en MD Anderson en Cooper e investigador principal de varios estudios TIL.<\/p>\n

\u201cLos resultados de la investigaci\u00f3n publicados en las principales revistas m\u00e9dicas, como New England Journal of Medicine, han demostrado que la terapia TIL no solo prolonga la vida de las personas con melanoma avanzado, sino que tambi\u00e9n permite que algunas tengan respuestas completas, incluso despu\u00e9s de fallar en el est\u00e1ndar anterior de -cuidado de la inmunoterapia\u201d, dice el Dr. Hong.<\/p>\n

El Dr. Hong, que dirige el equipo de TIL en MD Anderson en Cooper, aporta una experiencia \u00fanica en este tratamiento de su trabajo de investigaci\u00f3n anterior con la terapia TIL en los Institutos Nacionales de Salud.<\/p>\n

C\u00f3mo funciona la terapia TIL<\/strong><\/p>\n

Despu\u00e9s de luchar contra el c\u00e1ncer durante tanto tiempo, las c\u00e9lulas T de un paciente se agotan y ya no son efectivas. La terapia TIL reemplaza estas c\u00e9lulas T ineficaces con las propias c\u00e9lulas T potenciadas y cultivadas en el laboratorio del paciente que pueden renovar la lucha contra el melanoma.<\/p>\n

Primero, se extrae el tumor de melanoma del paciente y se env\u00eda a un laboratorio especial. En el laboratorio, las c\u00e9lulas T que combaten el c\u00e1ncer del paciente se a\u00edslan del tumor. Se revitalizan, se cultivan en miles de millones de c\u00e9lulas y luego se congelan.<\/p>\n

Cuando las nuevas c\u00e9lulas T est\u00e1n listas, el paciente recibe un tratamiento intensivo de quimioterapia para eliminar las c\u00e9lulas reguladoras, que suprimen la respuesta inmunitaria del cuerpo. Luego, las c\u00e9lulas T reforzadas cultivadas en laboratorio se devuelven al paciente a trav\u00e9s de una infusi\u00f3n. En este punto, las \u00fanicas c\u00e9lulas T en el cuerpo del paciente son sus propias c\u00e9lulas que combaten el c\u00e1ncer sobrealimentadas. Luego, los pacientes reciben entre una y seis dosis de un medicamento llamado IL2, que aumenta a\u00fan m\u00e1s la eficacia de las c\u00e9lulas T.<\/p>\n

Las nuevas c\u00e9lulas T del paciente se regeneran y forman c\u00e9lulas de memoria duraderas, que buscan y atacan continuamente nuevas c\u00e9lulas cancerosas.<\/p>\n

\u201cLa investigaci\u00f3n ha documentado numerosos pacientes que se han curado de su melanoma metast\u00e1sico durante m\u00e1s de 10 a\u00f1os con este tratamiento\u201d, dice el Dr. Hong.<\/p>\n

\u201cEl equipo de MD Anderson at Cooper se enorgullece de ser uno de los pocos centros selectos del pa\u00eds que puede brindar este tratamiento de inmunoterapia personalizado a nuestros pacientes. Nuestro equipo tambi\u00e9n participa y lidera ensayos cl\u00ednicos para el uso de la terapia TIL para otros tipos de c\u00e1ncer, incluido el c\u00e1ncer de pulm\u00f3n de c\u00e9lulas no peque\u00f1as metast\u00e1sico. Esta terapia se ha utilizado anteriormente en el tratamiento de pacientes con c\u00e1nceres ginecol\u00f3gicos y c\u00e1nceres de cabeza y cuello\u201d.<\/p>\n

Para obtener m\u00e1s informaci\u00f3n sobre la terapia TIL para melanoma avanzado y otros ensayos cl\u00ednicos de c\u00e1ncer en MD Anderson at Cooper, llame al 855.MDA.COOPER<\/a> (855.632.2667<\/a>) o env\u00ede un correo electr\u00f3nico a: researchcancer@cooperhealth.edu<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Para leer en Espa\u00f1ol, por favor haga clic aqu\u00ed Researchers at MD Anderson Cancer Center at Cooper are leading the way in clinical trials of a new approach to treating advanced melanoma using tumor infiltrating lymphocyte (TIL) therapy. \u201cTIL therapy is a promising, personalized approach to cancer treatment,\u201d says Young Ki Hong, MD, MPH, surgical … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":48,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-tlaverty","4":"post-12455","6":"format-standard","7":"category-ehealth-connection"},"yoast_head":"\nA Groundbreaking Approach to Treating Advanced Melanoma \u2013 Now Available at MD Anderson Cancer Center at Cooper - eHealth Connection<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.cooperhealth.org\/ehealth\/2023\/02\/08\/a-groundbreaking-approach-to-treating-advanced-melanoma-now-available-at-md-anderson-cancer-center-at-cooper\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A Groundbreaking Approach to Treating Advanced Melanoma \u2013 Now Available at MD Anderson Cancer Center at Cooper - eHealth Connection\" \/>\n<meta property=\"og:description\" content=\"Para leer en Espa\u00f1ol, por favor haga clic aqu\u00ed Researchers at MD Anderson Cancer Center at Cooper are leading the way in clinical trials of a new approach to treating advanced melanoma using tumor infiltrating lymphocyte (TIL) therapy. \u201cTIL therapy is a promising, personalized approach to cancer treatment,\u201d says Young Ki Hong, MD, MPH, surgical ... 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