{"id":13900,"date":"2025-03-31T09:56:49","date_gmt":"2025-03-31T13:56:49","guid":{"rendered":"https:\/\/blogs.cooperhealth.org\/news\/?p=13900"},"modified":"2026-02-09T11:42:27","modified_gmt":"2026-02-09T16:42:27","slug":"cooper-university-health-care-and-university-of-iowa-health-care-to-launch-large-study-of-rapid-innovative-stroke-triage-strategies","status":"publish","type":"post","link":"https:\/\/blogs.cooperhealth.org\/news\/2025\/03\/cooper-university-health-care-and-university-of-iowa-health-care-to-launch-large-study-of-rapid-innovative-stroke-triage-strategies\/","title":{"rendered":"Cooper University Health Care and University of Iowa Health Care to Launch Large Study of Rapid, Innovative Stroke Triage Strategies"},"content":{"rendered":"

Landmark study aims to optimize emergency stroke care and improve outcomes for thousands of thrombectomy patients nationwide<\/em><\/p>\n

\"\"

Tudor Jovin, MD<\/p><\/div>\n

Cooper University Health Care, in collaboration with the University of Iowa Health Care, has been awarded research funding by the Patient-Centered Outcomes Research Institute (PCORI) to support a large clinical trial comparing two triage strategies for guiding thrombectomy, a life-saving intervention for patients with large vessel occlusion (LVO) strokes, the most severe and disabling subtype of ischemic stroke.<\/p>\n

The study, called DIRECT<\/a>, is led by Santiago Ortega-Guti\u00e9rrez, MD, MSc, clinical professor of neurology, neurosurgery, and radiology at UI Health Care, and Tudor Jovin, MD, medical director of Cooper and Inspira Neuroscience<\/a> and professor of neurology and neurological surgery at Cooper Medical School of Rowan University. The study seeks to determine whether using a direct-to-angiosuite approach\u2014designed to streamline care and reduce time to thrombectomy\u2014can improve outcomes by speeding up the decision-making process of using thrombectomy. The study will also determine if such an approach increases patient risk as compared to the conventional emergency department triage process.<\/p>\n

Faster stroke care saves lives<\/strong><\/p>\n

Stroke remains a leading cause of long-term disability, affecting more than 795,000 people annually in the United States. LVO strokes, which are caused by blockages in major brain arteries, are particularly devastating, often resulting in profound and permanent impairments of a person\u2019s physical and mental abilities.<\/p>\n

Thrombectomy, a relatively new advancement in stroke care, involves using a catheter inserted through the groin or through the wrist, to access the blocked artery in the brain and mechanically remove the blood clot, restoring blood flow. This procedure, performed by highly trained neuro-interventionalists, has proved to be a lifesaving and disability-sparing therapy. The procedure\u2019s effectiveness hinges on speed \u2014 every minute of delay leads to the loss of thousands of brain cells. Therefore, it is critical to identify patients who have had an LVO as quickly as possible so that thrombectomy can be started without delay.<\/p>\n

In current practice, stroke patients are typically triaged in the emergency department (ED), where multiple imaging steps may delay treatment decisions. To address this, some hospitals have adopted a direct-to-angiosuite approach, where patients with suspected LVO are taken directly to the operating room, or neurointerventional suite, for initiating thrombectomy, bypassing the ED, and using a flat-panel CT scan imaging in the angiosuite to rule out brain hemorrhage.<\/p>\n

“Time is brain, and in LVO patients, imaging often takes too long\u2014so, in many ways, imaging is brain, too,\u201d says Dr. Ortega-Guti\u00e9rrez, DIRECT study co-principal investigator. \u201cIn our recent investigations, we\u2019ve shown that a direct-to-angiosuite strategy can accelerate treatment initiation by at least 30 minutes, a time savings that can mean the difference between recovery and lifelong disability. Every minute matters when treating large vessel occlusion strokes, and this study is a landmark opportunity to rigorously evaluate this approach across diverse health care systems in the United States.<\/p>\n

“By confirming the benefits of this streamlined strategy, we aim to reshape stroke care paradigms and ensure that patients, regardless of where they are treated, have access to faster, more effective interventions. This study has the potential to revolutionize the standard of care for suspected LVO strokes nationwide,\u201d he adds.<\/p>\n

A nationwide study to transform stroke triage<\/strong><\/p>\n

The DIRECT trial will enroll more than 2,000 patients across 20 leading thrombectomy centers in the U.S. to compare direct-to-angiosuite versus conventional ED triage strategies in real-world stroke care.<\/p>\n

\u201cThis trial is monumental in scale and significance,\u201d says Dr. Jovin, DIRECT study co-principal investigator. \u201cWith more than 20 participating centers nationwide, we are poised to generate practice-changing evidence that addresses a critical gap in stroke care. Our findings will provide clinicians, hospitals, and policymakers with clear guidance on optimizing triage strategies to improve patient outcomes.\u201d<\/p>\n

\u201cThis study is not just about data\u2014it\u2019s about transforming care for patients facing one of the most severe and time-sensitive neurological emergencies,\u201d adds Jorge Cespedes, MD, UI postdoctoral researcher and the DIRECT trial manager.<\/p>\n

Patients enrolled in the study will contribute clinical data during hospitalization and complete follow-up assessments at three months, focusing on recovery, disability, and quality-of-life outcomes.<\/p>\n

This study was selected through PCORI\u2019s highly competitive review process in which patients, caregivers and other stakeholders join scientists to evaluate proposals.<\/p>\n

Pragmatic clinical studies, such as this, test a treatment\u2019s effectiveness in real-world clinical situations such as standard hospitals and outpatient clinics, and can include a wider range of study participants, making their findings more generally applicable.<\/p>\n

About Cooper and Inspira Neuroscience<\/strong><\/p>\n

The Cooper and Inspira Neuroscience is a partnership of Cooper University Health Care and Inspira Health that is fully dedicated to the diagnosis and treatment of neurological and neurosurgical issues. The partnership improves local access to a comprehensive range of advanced neuroscience care including surgical and nonsurgical services related to the brain, spinal cord, and central nervous system.<\/p>\n

The Cooper University Health Care’s Stroke Program<\/a> has received The Joint Commission\u2019s Gold Seal of Approval\u00ae and the American Heart Association\/American Stroke Association\u2019s Heart-Check mark for Advanced Certification for Comprehensive Stroke Centers. The Gold Seal of Approval\u00ae and the Heart-Check mark represent hospitals with the highest level of stroke care and are symbols of quality from their respective organizations.<\/p>\n

About University of Iowa Health Care <\/strong><\/p>\n

University of Iowa Health Care, Iowa\u2019s only comprehensive academic health system, leads the way in improving health care by providing the most advanced care for patients in Iowa, educating the next generation of physicians, and making new biomedical research discoveries. The nearly 20,000 faculty and staff who are part of UI Health Care share a commitment to care for all Iowans, with a mission of changing medicine and changing lives.<\/p>\n

Visit uihealthcare.org for more information.<\/p>\n

—-<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Landmark study aims to optimize emergency stroke care and improve outcomes for thousands of thrombectomy patients nationwide Cooper University Health Care, in collaboration with the University of Iowa Health Care, has been awarded research funding by the Patient-Centered Outcomes Research Institute (PCORI) to support a large clinical trial comparing two triage strategies for guiding thrombectomy, … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":66,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,7978],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-wmarano","4":"post-13900","6":"format-standard","7":"category-press-releases","8":"category-research"},"yoast_head":"\nCooper University Health Care and University of Iowa Health Care to Launch Large Study of Rapid, Innovative Stroke Triage Strategies - Inside Cooper<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.cooperhealth.org\/news\/2025\/03\/cooper-university-health-care-and-university-of-iowa-health-care-to-launch-large-study-of-rapid-innovative-stroke-triage-strategies\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cooper University Health Care and University of Iowa Health Care to Launch Large Study of Rapid, Innovative Stroke Triage Strategies - Inside Cooper\" \/>\n<meta property=\"og:description\" content=\"Landmark study aims to optimize emergency stroke care and improve outcomes for thousands of thrombectomy patients nationwide Cooper University Health Care, in collaboration with the University of Iowa Health Care, has been awarded research funding by the Patient-Centered Outcomes Research Institute (PCORI) to support a large clinical trial comparing two triage strategies for guiding thrombectomy, ... 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