{"id":14226,"date":"2026-04-28T11:03:06","date_gmt":"2026-04-28T15:03:06","guid":{"rendered":"https:\/\/blogs.cooperhealth.org\/news\/?p=14226"},"modified":"2026-04-28T11:03:06","modified_gmt":"2026-04-28T15:03:06","slug":"cooper-innovation-center-announces-license-agreement-and-venture-financing-for-upstream-access-a-cooper-founded-medical-device-startup","status":"publish","type":"post","link":"https:\/\/blogs.cooperhealth.org\/news\/2026\/04\/cooper-innovation-center-announces-license-agreement-and-venture-financing-for-upstream-access-a-cooper-founded-medical-device-startup\/","title":{"rendered":"Cooper Innovation Center Announces License Agreement and Venture Financing for Upstream Access, a Cooper-Founded Medical Device Startup"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-14228 alignleft\" src=\"https:\/\/blogs.cooperhealth.org\/news\/files\/2026\/04\/Jeffrey-Carpenter-resized-scaled.jpg\" alt=\"\" width=\"199\" height=\"298\" srcset=\"https:\/\/blogs.cooperhealth.org\/news\/files\/2026\/04\/Jeffrey-Carpenter-resized-scaled.jpg 1707w, https:\/\/blogs.cooperhealth.org\/news\/files\/2026\/04\/Jeffrey-Carpenter-resized-200x300.jpg 200w, https:\/\/blogs.cooperhealth.org\/news\/files\/2026\/04\/Jeffrey-Carpenter-resized-683x1024.jpg 683w, https:\/\/blogs.cooperhealth.org\/news\/files\/2026\/04\/Jeffrey-Carpenter-resized-768x1152.jpg 768w, https:\/\/blogs.cooperhealth.org\/news\/files\/2026\/04\/Jeffrey-Carpenter-resized-1024x1536.jpg 1024w, https:\/\/blogs.cooperhealth.org\/news\/files\/2026\/04\/Jeffrey-Carpenter-resized-1365x2048.jpg 1365w, https:\/\/blogs.cooperhealth.org\/news\/files\/2026\/04\/Jeffrey-Carpenter-resized-800x1200.jpg 800w\" sizes=\"auto, (max-width: 199px) 100vw, 199px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-14227 alignleft\" src=\"https:\/\/blogs.cooperhealth.org\/news\/files\/2026\/04\/Katherine-McMackin-MD-scaled.jpg\" alt=\"\" width=\"188\" height=\"293\" srcset=\"https:\/\/blogs.cooperhealth.org\/news\/files\/2026\/04\/Katherine-McMackin-MD-scaled.jpg 1645w, https:\/\/blogs.cooperhealth.org\/news\/files\/2026\/04\/Katherine-McMackin-MD-193x300.jpg 193w, https:\/\/blogs.cooperhealth.org\/news\/files\/2026\/04\/Katherine-McMackin-MD-658x1024.jpg 658w, https:\/\/blogs.cooperhealth.org\/news\/files\/2026\/04\/Katherine-McMackin-MD-768x1195.jpg 768w, https:\/\/blogs.cooperhealth.org\/news\/files\/2026\/04\/Katherine-McMackin-MD-987x1536.jpg 987w, https:\/\/blogs.cooperhealth.org\/news\/files\/2026\/04\/Katherine-McMackin-MD-1316x2048.jpg 1316w, https:\/\/blogs.cooperhealth.org\/news\/files\/2026\/04\/Katherine-McMackin-MD-771x1200.jpg 771w\" sizes=\"auto, (max-width: 188px) 100vw, 188px\" \/>Cooper University Health Care\u2019s <a href=\"https:\/\/www.cooperhealth.edu\/cooper-innovation-center\">Innovation Center<\/a> has announced a license agreement with <a href=\"http:\/\/www.upstreamaccessinc.com\">Upstream Access, Inc.,<\/a> a Cooper-founded, physician-led medical device startup developing a novel multi-directional vascular access system designed to improve endovascular procedures for patients with peripheral artery disease (PAD) and other vascular conditions.<\/p>\n<p>The technology was invented at Cooper by Katherine McMackin, MD, MS, a vascular surgeon and director of vascular surgery research at Cooper University Health Care and assistant professor of surgery at Cooper Medical School of Rowan University, and Jeffrey P. Carpenter, MD, professor of surgery at Cooper Medical School of Rowan University and a nationally recognized vascular surgeon who remains active with Cooper University Health Care following his retirement from clinical practice.<\/p>\n<p>Concurrently with the execution of the license agreement, Foundation Venture Capital Group (FVCG), an affiliate of the New Jersey Health Foundation (NJHF), has committed $500,000 in initial equity financing to Upstream Access. This investment builds on early grant funding, strategic guidance, and hands-on commercialization support provided by NJHF, which helped advance the technology from initial development through company formation. Upstream Access is currently pursuing a total financing round of $500,000 to $1 million to support upcoming development and regulatory milestones.<\/p>\n<p><strong>Addressing an Unmet Need in Vascular Care<\/strong><\/p>\n<p>The Upstream Access Multi-Directional Vascular Access System is designed to enable both antegrade and retrograde access through a single-entry point, reducing the need for additional access sites and improving overall procedural efficiency.<\/p>\n<p>The novelty of the system arises from two unique components:<\/p>\n<ul>\n<li>Balloon-Anchoring Sheath: An inflatable anchoring mechanism secures the sheath within the vessel wall, reducing trauma or obstruction of blood flow. Its design allows users to pivot the sheath around the balloon-anchor to transition from antegrade to retrograde access from a single needle stick.<\/li>\n<li>Steerable U-Turn Catheter: A tightly curved, steerable catheter enables precise 360\u2011degree wire placement in any direction, with directional markers on the hub to guide catheter rotation.<\/li>\n<\/ul>\n<p>\u201cUpstream Access is pleased to partner with Cooper University Health Care and the New Jersey Health Foundation to further the development of our groundbreaking technology, which reduces the number of procedures needed to treat patients with vascular disease, thereby decreasing the likelihood of complications. We look forward to bringing this exciting interventional product to market,\u201d said Dr. Carpenter, who also serves as chief scientific officer for Upstream Access.<\/p>\n<p>\u201cWith vascular disease, we are often trying to treat complex, multi\u2011level pathology using access tools that were designed to work in only one direction,\u201d said Dr. McMackin, the company\u2019s president and CEO. \u201cThat limitation frequently forces physicians to create additional access sites or to stage procedures, which increases risk for patients. The Upstream Access system was designed to give vascular interventionists more options from a single-entry point, with the goal of simplifying procedures, reducing complications, and ultimately improving care for patients with vascular disease.\u201d<\/p>\n<p><strong>Development and Commercialization Pathway<\/strong><\/p>\n<p><a href=\"http:\/\/www.upstreamaccessinc.com\">Upstream Access<\/a> has completed early development and proof\u2011of\u2011concept testing and is currently in the prototype refinement phase. A U.S. provisional patent application has been filed, and regulatory consultants have identified a 510(k) FDA pathway.<\/p>\n<p>\u201cUpstream Access represents the type of clinician-driven innovation we seek to support\u2014technologies grounded in real clinical challenges with a clear pathway to commercialization,\u201d said James Golubieski, president and CEO of Foundation Venture Capital Group. \u201cThis investment reflects our confidence in the team and in the opportunity to bring a differentiated vascular access solution to market.\u201d<\/p>\n<p>The newly committ<\/p>\n<p>&nbsp;<\/p>\n<p>ed financing will support continued prototype refinement, verification and validation testing, regulatory strategy development, and commercialization planning, positioning the company for future clinical and market entry milestones.<\/p>\n<p>\u201cExecuting the license agreement and securing venture financing represent a major step forward for this technology and for Cooper\u2019s growing innovation ecosystem,\u201d said Neal Lemon, PhD, MBA, director of the Cooper Innovation Center. \u201cUpstream Access exemplifies<\/p>\n<p>The launch of Upstream Access marks a significant milestone for Cooper\u2019s innovation mission, representing one of the earliest medical device startup companies to spin out of Cooper and establish operations in Camden. The company exemplifies the Innovation Center\u2019s approach to building locally anchored, physician\u2011led ventures and underscores Cooper\u2019s strategy to keep clinician\u2011invented technologies local, supporting startup formation, job creation, and commercialization activity in the city where these innovations originate, while advancing patient care and contributing to regional economic growth.<\/p>\n<p><strong>About Cooper University Health Care<\/strong><br \/>\nCooper University Health Care is a leading academic health system affiliated with Cooper Medical School of Rowan University. Cooper, headquartered in Camden, New Jersey, has revenues of more than $2.4 billion and an A+ credit rating from both S&amp;P and Fitch Ratings.<\/p>\n<p>Cooper has nearly 14,000 team members, including nearly 2,200 nurses, more than 1,200 employed physicians representing 95 specialties and subspecialties, and more than 700 advanced practice providers. how Cooper clinicians are translating real\u2011world clinical challenges into venture\u2011backed companies with the potential to improve patient care.\u201d<\/p>\n<p>Cooper operates MD Anderson Cancer Center at Cooper as well as three hospitals \u2013 its 663-bed flagship Cooper University Hospital in Camden, its 229-bed Cooper University Hospital Cape Regional in Cape May Court House, and Children\u2019s Regional Hospital in Camden.<\/p>\n<p>Cooper University Hospital in Camden is the only Level 1 trauma center in South Jersey and the busiest in the region. The hospital has been recognized as a top-performing regional hospital by U.S. News &amp; World Report\u2019s Best Hospitals annual survey for six years.<\/p>\n<p>More than 2.54 million patients visit Cooper\u2019s facilities annually. Cooper\u2019s ambulatory network encompasses three outpatient surgery centers, seven urgent care centers, a wound care center, and more than 130 physician, physical therapy, and radiology offices extending from the Delaware River to the New Jersey shore.<\/p>\n<p>Cooper was named one of America\u2019s Best Large Employers for 2026 by Forbes, ranking among the top 200 in the nation. Visit <a href=\"https:\/\/www.cooperhealth.org\/\">CooperHealth.org<\/a> to learn more.<\/p>\n<p><strong>About the Foundation Venture Capital Group<\/strong><\/p>\n<p><a href=\"https:\/\/urldefense.com\/v3\/__https:\/www.foundationventure.com\/__;!!HslpFqnNwYzYOafRKtc!esnOgz7YGyEn5VQhPhgdg2wIFJIzqtAvzCVUelhx2NUJJKVkN-KaLeoFxhbIrzJFZ0mD-ztejOVmLNuFdQ$\">Foundation Venture Capital Group<\/a>\u00a0(FVCG) is a Princeton, New Jersey based organization that uses impact investing to provide pre-seed and seed funding to health-related start-up companies at their partner organizations to help them advance toward and through commercialization. FVCG is an affiliate of the\u00a0<a href=\"https:\/\/urldefense.com\/v3\/__https:\/www.njhealthfoundation.org\/__;!!HslpFqnNwYzYOafRKtc!esnOgz7YGyEn5VQhPhgdg2wIFJIzqtAvzCVUelhx2NUJJKVkN-KaLeoFxhbIrzJFZ0mD-ztejOXUpnl0fg$\">New Jersey Health Foundation<\/a>, a not-for-profit corporation that supports health-related research and education programs in New Jersey through its\u00a0<a href=\"https:\/\/urldefense.com\/v3\/__https:\/www.njhealthfoundation.org\/research-grant-program__;!!HslpFqnNwYzYOafRKtc!esnOgz7YGyEn5VQhPhgdg2wIFJIzqtAvzCVUelhx2NUJJKVkN-KaLeoFxhbIrzJFZ0mD-ztejOUOjG4LQA$\">Research\/Community Health and Social Service grant programs<\/a> and its <a href=\"https:\/\/urldefense.com\/v3\/__https:\/www.foundationforhealthadvancement.org\/innovation-grants-program__;!!HslpFqnNwYzYOafRKtc!esnOgz7YGyEn5VQhPhgdg2wIFJIzqtAvzCVUelhx2NUJJKVkN-KaLeoFxhbIrzJFZ0mD-ztejOVjdhkTvg$\">Innovation Grant program<\/a>.<\/p>\n<p>###<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cooper University Health Care\u2019s Innovation Center has announced a license agreement with Upstream Access, Inc., a Cooper-founded, physician-led medical device startup developing a novel multi-directional vascular access system designed to improve endovascular procedures for patients with peripheral artery disease (PAD) and other vascular conditions. The technology was invented at Cooper by Katherine McMackin, MD, MS, &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/blogs.cooperhealth.org\/news\/2026\/04\/cooper-innovation-center-announces-license-agreement-and-venture-financing-for-upstream-access-a-cooper-founded-medical-device-startup\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":66,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-wmarano","4":"post-14226","6":"format-standard","7":"category-press-releases"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Cooper Innovation Center Announces License Agreement and Venture Financing for Upstream Access, a Cooper-Founded Medical Device Startup - Inside Cooper<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.cooperhealth.org\/news\/2026\/04\/cooper-innovation-center-announces-license-agreement-and-venture-financing-for-upstream-access-a-cooper-founded-medical-device-startup\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cooper Innovation Center Announces License Agreement and Venture Financing for Upstream Access, a Cooper-Founded Medical Device Startup - Inside Cooper\" \/>\n<meta property=\"og:description\" content=\"Cooper University Health Care\u2019s Innovation Center has announced a license agreement with Upstream Access, Inc., a Cooper-founded, physician-led medical device startup developing a novel multi-directional vascular access system designed to improve endovascular procedures for patients with peripheral artery disease (PAD) and other vascular conditions. The technology was invented at Cooper by Katherine McMackin, MD, MS, ... 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