{"id":8658,"date":"2018-02-01T09:52:38","date_gmt":"2018-02-01T14:52:38","guid":{"rendered":"http:\/\/blogs.cooperhealth.org\/news\/?p=8658"},"modified":"2018-02-01T09:52:38","modified_gmt":"2018-02-01T14:52:38","slug":"too-much-oxygen-may-be-harmful-not-helpful-following-cardiac-arrest-cooper-researchers-find","status":"publish","type":"post","link":"https:\/\/blogs.cooperhealth.org\/news\/2018\/02\/too-much-oxygen-may-be-harmful-not-helpful-following-cardiac-arrest-cooper-researchers-find\/","title":{"rendered":"Too Much Oxygen\u00a0May Be Harmful, Not Helpful Following Cardiac Arrest, Cooper Researchers Find"},"content":{"rendered":"<h2>Pivotal Study to be Published in Leading Medical Journal<\/h2>\n<p>Compelling new evidence demonstrates that too much oxygen following cardiac arrest may be harmful, not helpful to patients according to researchers at <a href=\"http:\/\/cooperhealth.org\/\">Cooper University Health Care<\/a> and <a href=\"http:\/\/cmsru.rowan.edu\/\">Cooper Medical School of Rowan University<\/a>. The results of their multi-center study on this topic, which was funded by a grant from the National Institutes of Health (NIH), will be published in <a href=\"http:\/\/circ.ahajournals.org\/\">Circulation, the journal of the American Heart Association<\/a>.<\/p>\n<p><a href=\"http:\/\/circ.ahajournals.org\/content\/early\/2018\/01\/25\/CIRCULATIONAHA.117.032054\">Click here<\/a> to read the article.<\/p>\n<p>\u201cOur research set out to answer the often debated question about the optimal level of oxygen concentration for patients once they have been resuscitated from cardiac arrest,\u201d explained <a href=\"https:\/\/www.cooperhealth.org\/doctors\/stephen-trzeciak-md\">Stephen Trzeciak, MD, MPH<\/a>, the Principal Investigator of the research and Professor of Medicine at Cooper. \u201cThere have been conflicting results with historical studies, but our latest research results support the hypothesis that too much oxygen after the patient has been revived can intensify brain damage in these situations.\u201d<\/p>\n<p>\u201cWhen a patient experiences cardiac arrest, the brain cells are deprived of oxygen, and this can result in permanent brain damage,\u201d said <a href=\"https:\/\/www.cooperhealth.org\/doctors\/j-hope-kilgannon-md\">Hope Kilgannon, MD<\/a>, Emergency Medicine specialist at Cooper, Associate Professor of Emergency Medicine, and co-author of the study. \u201cThe brain damage may actually be intensified if too much oxygen is given once blood flow is restored.\u201d<\/p>\n<p>Conventionally, patients are administered 100 percent oxygen during cardiac arrest and resuscitation in attempts to get the heart restarted. However, after the heart is successfully restarted, the optimal level of oxygen that the patient needs has been a source of controversy among physicians.<\/p>\n<p>Cooper\u2019s researchers have been studying this issue for a number of years as part of the NIH-funded research grant. In 2010, the Journal of the American Medical Association (JAMA) published the research team\u2019s results of the first large-scale report of outcomes in humans. The initial study included information from a critical care database of patients at 120 U.S. hospitals, and showed that patients with exposure to excessively high oxygen levels in the blood \u2013 a condition referred\u00a0to as hyperoxia \u2013 had the highest mortality rate of all subjects in the study, even compared to those with persistently low oxygen levels.<\/p>\n<p>Cooper University Hospital was the coordinating center for the newest study, conducted in collaboration with Indiana University School of Medicine; University of Mississippi Medical Center; Beth Israel Deaconess Medical Center in Boston; Penn-Presbyterian Medical Center in Philadelphia; and the Hospital of the University of Pennsylvania.<\/p>\n<p>Of\u00a0280 adult patients resuscitated from cardiac arrest at these six hospitals across the United States, 105 (38 percent) had exposure to hyperoxia. Seventy\u00a0percent of the 280 patients\u00a0died in the hospital or survived to hospital discharge with severe brain injury.\u00a0 Patients with exposure to hyperoxia were more likely to die or survive\u00a0with severe brain injury\u00a0(77 percent vs. 65 percent among patients with and without exposure to hyperoxia respectively).\u00a0 Additionally, further analysis showed that on average for every\u00a0one-hour longer duration of hyperoxia exposure\u00a0there was an additional 3 percent increase in\u00a0patients&#8217;\u00a0risk of death or severe brain injury.<\/p>\n<p>\u201cWhile intuitively it may seem that more oxygen is better, the conclusions of this study support our hypothesis that excessively high oxygen levels after resuscitation from cardiac arrest may actually cause further harm to patients,\u201d said Dr. Trzeciak. \u00a0\u201cThe next step in this line of research is a clinical trial to determine the best method of reducing supplemental oxygen and preventing hyperoxia exposure, to improve outcomes for victims of cardiac arrest.\u201d<\/p>\n<p>###<\/p>\n<h3>Contacts<\/h3>\n<p>Wendy A. Marano, Public Relations Manager<br \/>\nCooper University Health Care<br \/>\nmarano-wendy@cooperhealth.edu<br \/>\n856.382.6463<\/p>\n<p>Sharon R. Clark, Director, Marketing and PR<br \/>\nCooper Medical School of Rowan University<br \/>\n<a href=\"mailto:clarks@rowan.edu\">clarks@rowan.edu<\/a><br \/>\nOffice: 856.361.2825<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pivotal Study to be Published in Leading Medical Journal Compelling new evidence demonstrates that too much oxygen following cardiac arrest may be harmful, not helpful to patients according to researchers at Cooper University Health Care and Cooper Medical School of Rowan University. The results of their multi-center study on this topic, which was funded by &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/blogs.cooperhealth.org\/news\/2018\/02\/too-much-oxygen-may-be-harmful-not-helpful-following-cardiac-arrest-cooper-researchers-find\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14,6],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-rmineo","4":"post-8658","6":"format-standard","7":"category-in-the-news","8":"category-press-releases"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Too Much Oxygen\u00a0May Be Harmful, Not Helpful Following Cardiac Arrest, Cooper Researchers Find - Inside Cooper<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.cooperhealth.org\/news\/2018\/02\/too-much-oxygen-may-be-harmful-not-helpful-following-cardiac-arrest-cooper-researchers-find\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Too Much Oxygen\u00a0May Be Harmful, Not Helpful Following Cardiac Arrest, Cooper Researchers Find - Inside Cooper\" \/>\n<meta property=\"og:description\" content=\"Pivotal Study to be Published in Leading Medical Journal Compelling new evidence demonstrates that too much oxygen following cardiac arrest may be harmful, not helpful to patients according to researchers at Cooper University Health Care and Cooper Medical School of Rowan University. The results of their multi-center study on this topic, which was funded by ... 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